Excitation of hippocampal neurons by stimulation of glutamate Qp receptors
| Autor: | Paul F. Worley, Jay M. Baraban, Kathleen R. Stratton |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
AMPA receptor Biology Hippocampal formation In Vitro Techniques Hippocampus chemistry.chemical_compound Quinoxalines Animals Quisqualic acid Cycloleucine Receptor Ibotenic Acid alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Pharmacology 6-Cyano-7-nitroquinoxaline-2 3-dione Neurons Oxadiazoles Glutamate receptor Quisqualic Acid Depolarization Receptors Muscarinic Electric Stimulation Rats Receptors Neurotransmitter Electrophysiology chemistry Receptors Glutamate Excitatory postsynaptic potential Neuroscience Ionotropic effect |
| Zdroj: | European journal of pharmacology. 173(2-3) |
| ISSN: | 0014-2999 |
| Popis: | The electrophysiological effects of Qp receptors activation in brain neurons are investigated in rat hippocampal slice preparation. Quisqualate, in the presence of a ionotropic quisqualate receptor antagonist that does not block Qp receptor activation, produces a depolarization associated with an increased membrane resistance. All results indicate that the recently identified glutamate Qp receptor subtype may play an important role in the regulation of neuronal excitability by excitatory amino acid transmitters |
| Databáze: | OpenAIRE |
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