Prognostic role of transferrin saturation in heart failure patients
| Autor: | Piergiuseppe Agostoni, Irene Motta, M.D. Cappellini, Alice Bonomi, Jeness Campodonico, Margherita Migone De Amicis, Flavia Nicoli |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Epidemiology Renal function Gastroenterology Interquartile range Internal medicine medicine Humans Risk factor Survival rate Heart Failure Anemia Iron-Deficiency biology business.industry Transferrin saturation Mortality rate Transferrin Prognosis medicine.disease Ferritin Heart failure Ferritins biology.protein Transferrins Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Journal of Preventive Cardiology. 28:1639-1646 |
| ISSN: | 2047-4881 2047-4873 |
| DOI: | 10.1093/eurjpc/zwaa112 |
| Popis: | Aims In heart failure (HF) iron deficiency (ID) is frequently observed and represents a major mortality risk factor. Purpose of this study was to evaluate the correlation between mortality and ID in a cohort of 661 consecutive patients hospitalized for HF worsening. Methods and results Patients were grouped: (i)according to presence(+)/absence(−) of anaemia (A) and ID defined following World Health Organization (WHO) and European Society of Cardiology (ESC)–American College of Cardiology/American Heart Association/HF society of America (ACC/AHA/HFSA) definitions, respectively: Group A−ID− (n = 123), Group A+ID− (n = 80), Group A+ID+ (n = 247), and Group A−ID+ (n = 211); (ii) according to presence of absolute (serum ferritin < 100μg/L) and functional ID [ferritin between 100 and 300μg/L and transferrin saturation (TSAT) < 20%]; and (iii) according to TSAT Conclusion We confirmed that in HF anaemia is associated to a poor prognosis. Moreover, we showed that patients with TSAT |
| Databáze: | OpenAIRE |
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