Soft drugs in anesthesia: remifentanil as prototype to modern anesthetic drug development
Autor: | Talmage D. Egan, Ami R. Stuart, Nathaniel M Birgenheier |
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Rok vydání: | 2020 |
Předmět: |
Drug
medicine.medical_specialty Chemistry Pharmaceutical media_common.quotation_subject Remifentanil 03 medical and health sciences 0302 clinical medicine Anesthesiology 030202 anesthesiology Etomidate Humans Medicine Anesthesia Adverse effect Anesthetics media_common business.industry Analgesics Opioid Anesthesiology and Pain Medicine Drug development Drug Design Anesthetic business Remimazolam 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Current Opinion in Anaesthesiology. 33:499-505 |
ISSN: | 1473-6500 0952-7907 |
DOI: | 10.1097/aco.0000000000000879 |
Popis: | Purpose of review The unique demands of modern anesthesia practice require that medications be effective, well tolerated, and efficient. These attributes are increasingly achieved with the soft drug approach, wherein novel active compounds are specifically designed to be susceptible to rapid biotransformation to inactive metabolites. The present review summarizes the historical background and recent trends in soft drug development in anesthesiology. Recent findings Soft drug development programs for propranadid, etomidate, and benzodiazepine analogues have been undertaken in recent years. Although all three drugs advanced into human trials, neuro-excitatory adverse effects hampered the propranadid and etomidate analogue projects. Remimazolam, the soft benzodiazepine analogue, is at an advanced stage of development, having already received regulatory approval or review in several countries. Summary With succinylcholine as the historical forerunner and remifentanil as the modern prototype, the soft drug paradigm continues to hold promise for the future of anesthesia drug development. |
Databáze: | OpenAIRE |
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