Salivary and serum antibody response against Neisseria meningitidis after vaccination with conjugate polysaccharide vaccines in Ethiopian volunteers
| Autor: | Dominique A. Caugant, Guro K. Bårnes, P. Fissiha, Demissew Beyene, Behailu Merdekios, Bereket Workalemahu, Abraham Aseffa, Paul A. Kristiansen, Lisbeth Meyer Næss |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Immunoglobulin A Adult Male Volunteers Saliva Adolescent Immunology Meningitis Meningococcal Neisseria meningitidis medicine.disease_cause Serogroup 03 medical and health sciences Young Adult 0302 clinical medicine Conjugate vaccine medicine Humans 030212 general & internal medicine Child Vaccines Conjugate biology medicine.diagnostic_test Vaccination Infant General Medicine Blood Proteins Virology Antibodies Bacterial 030104 developmental biology Immunoassay Child Preschool Antibody Formation biology.protein Female Ethiopia Antibody Conjugate |
| Zdroj: | Scandinavian Journal of Immunology |
| ISSN: | 0300-9475 |
| Popis: | Meningococcal conjugate vaccines induce serum antibodies crucial for protection against invasive disease. Salivary antibodies are believed to be important for hindering meningococcal acquisition and/or clearance of established carriage. In this study, we measured salivary IgA and IgG antibodies induced by vaccination with a monovalent serogroup A conjugate vaccine or a tetravalent A, C, W and Y conjugate vaccine, in comparison with antibody levels in serum. Saliva and serum samples from Ethiopian volunteers (1–29 years) collected before and eight times on a weekly basis after receiving the serogroup A conjugate vaccine, the tetravalent serogroup A, C, W and Y conjugate vaccine, or no vaccine (control group), were analysed using a multiplex microsphere immunoassay for antibody detection. Serogroup-specific IgG antibody levels in saliva increased significantly after vaccination with both vaccines. The monovalent serogroup A vaccine also induced an increase in salivary IgA antibodies. A strong correlation between serogroup-specific IgG antibodies in saliva and serum, and a somewhat lower correlation for IgA, was observed for all serogroups. There was also a strong correlation between specific secretory IgA and IgA antibodies in saliva for all serogroups. Meningococcal conjugate vaccines are able to elicit salivary antibodies against serogroup A, C, W and Y correlating with antibody levels in serum. The strong correlation between saliva and serum antibody levels indicates that saliva may be used as a surrogate of systemic antibody responses. |
| Databáze: | OpenAIRE |
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