Calcineurin inhibitors and hypertension: a role for pharmacogenetics?
| Autor: | Ewout J. Hoorn, Ron H.N. van Schaik, Dennis A. Hesselink, Teun van Gelder, Robert Zietse, Arthur D. Moes |
|---|---|
| Přispěvatelé: | Internal Medicine, Clinical Chemistry, Pharmacy |
| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
Polymorphism Genetic Side effect Drug-Related Side Effects and Adverse Reactions business.industry Calcineurin Inhibitors medicine.disease WNK4 Transplantation Calcineurin Pharmacogenetics Hypertension Genetics medicine Molecular Medicine Humans CYP3A5 business Kidney transplantation Thiazide medicine.drug |
| Zdroj: | Pharmacogenomics, 15(9), 1243-1251. Future Medicine Ltd. |
| ISSN: | 1462-2416 |
| DOI: | 10.2217/pgs.14.87 |
| Popis: | Hypertension is a common side effect of calcineurin inhibitors (CNIs), which are drugs used to prevent rejection after transplantation. Hypertension after kidney transplantation has been associated with earlier graft failure and higher cardiovascular mortality in the recipient. Recent data indicate that enzymes and transporters involved in CNI pharmacokinetics and pharmacodynamics, including CYP3A5, ABCB1, WNK4 and SPAK, are also associated with salt-sensitive hypertension. These insights raise the question whether polymorphisms in the genes encoding these proteins increase the risk of CNI-induced hypertension. Predicting who is at risk for CNI-induced hypertension may be useful for when selecting specific interventions, including dietary salt restriction, thiazide diuretics or a CNI-free immunosuppressive regimen. This review aims to explore the pharmacogenetics of CNI-induced hypertension, highlighting the knowns and unknowns. |
| Databáze: | OpenAIRE |
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