The clinical severity score of chronic actinic dermatitis correlates within vivophotoallergic reactions and the immunologic parameters related to a shift towards Th2 immunity from the Th2/Th1 balanced status in patients with chronic actinic dermatitis

Autor:	Ki-Ho Kim, Tae-Hoon Kim, Dong-Yeob Ko, Kyeong Hee Kim, Seung-Min Ha, Ki-Hoon Song, Seung-Hwan Choi
Rok vydání:	2016
Předmět:	Male 0301 basic medicine medicine.medical_specialty Immunology CCR4 Dermatology CXCR3 Immunoglobulin E Severity of Illness Index 03 medical and health sciences Th2 Cells In vivo Severity of illness medicine Humans Immunology and Allergy Chronic actinic dermatitis Cytotoxic T cell Radiology Nuclear Medicine and imaging cardiovascular diseases biology Dermatitis Photoallergic business.industry General Medicine Th1 Cells Eosinophil medicine.disease Eosinophils 030104 developmental biology medicine.anatomical_structure Chronic Disease biology.protein Female business
Zdroj:	Photodermatology, Photoimmunology & Photomedicine. 32:199-206
ISSN:	0905-4383
DOI:	10.1111/phpp.12244
Popis:	Background Chronic actinic dermatitis (CAD) has a more complicated pathogenetic basis than others. The clinical grading system and its correlations with the clinical and immunological parameters still remained to be investigated to define the nature of CAD in a more detailed manner. Objectives We investigated correlations of the clinical severity score of CAD (CSS-CAD) with the clinical and immunological parameters. Methods We evaluated 72 patients with CAD and classified them into three groups according to the CSS-CAD. We analysed total IgE level, peripheral blood (PB) eosinophil count, the ratio of Th2cell (CCR4 + CD4 +) percentage over Th1 cell (CXCR3 + CD4 +) percentage (Th2/Th1) and/or the sum of suppressor/cytotoxic T cells. Results The total IgE levels and the percentage of PB eosinophils were higher in the severer group than other groups. A shift towards Th2 from Th2/Th1 balanced status may be affected by total counts of suppressor T cells, and the patient with higher Th2/Th1 ratio than balanced status had the more proportion in the severer CSS-CAD group than other groups. Conclusion The CSS-CAD correlates with total IgE level, PB eosinophil count and a shift towards Th2 immunity from Th2/Th1. So we suggest the Th1/Th2 dysbalance may be affected by the CSS-CAD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90102bc4b83254e31add36317021ae3d https://doi.org/10.1111/phpp.12244 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.