Non-Invasive Radiofrequency-Induced Targeted Hyperthermia for the Treatment of Hepatocellular Carcinoma
| Autor: | Steven A. Curley, Mustafa Raoof |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Hyperthermia
Oncology Biological therapies medicine.medical_specialty Hepatocellular cancer Hepatology business.industry Non invasive Review Article 02 engineering and technology 021001 nanoscience & nanotechnology medicine.disease Bioinformatics 3. Good health 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Hepatocellular carcinoma Medicine lcsh:Diseases of the digestive system. Gastroenterology lcsh:RC799-869 0210 nano-technology business Median survival |
| Zdroj: | International Journal of Hepatology, Vol 2011 (2011) International Journal of Hepatology |
| ISSN: | 2090-3456 2090-3448 |
| Popis: | Targeted biological therapies for hepatocellular cancer have shown minimal improvements in median survival. Multiple pathways to oncogenesis leading to rapid development of resistance to such therapies is a concern. Non-invasive radiofrequency field-induced targeted hyperthermia using nanoparticles is a radical departure from conventional modalities. In this paper we underscore the need for innovative strategies for the treatment of hepatocellular cancer, describe the central paradigm of targeted hyperthermia using non-invasive electromagnetic energy, review the process of characterization and modification of nanoparticles for the task, and summarize data from cell-based and animal-based models of hepatocellular cancer treated with non-invasive RF energy. Finally, future strategies and challenges in bringing this modality from bench to clinic are discussed. |
| Databáze: | OpenAIRE |
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