Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection
| Autor: | Patrícia Lipari Pinto, Cristina Florindo, Patrícia Janeiro, Rita Loureiro Santos, Sandra Mexia, Hugo Rocha, Isabel Tavares de Almeida, Laura Vilarinho, Ana Gaspar |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Nutrition and Dietetics Infant Newborn Infant Vitamin B 12 Deficiency Doenças Genéticas Vitamin B 12 Early Diagnosis Pregnancy Total Homocysteine Hydroxocobalamin Humans Female Infant Health Vitamin B12 Deficiency Homocysteine Newborn Screening Biomarkers vitamin B12 deficiency newborn screening pregnancy total homocysteine methylmalonic acid Food Science Methylmalonic Acid |
| Zdroj: | Nutrients; Volume 14; Issue 20; Pages: 4397 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu14204397 |
| Popis: | The early diagnosis of and intervention in vitamin B12 deficiency in exclusively breastfed infants by mothers with low vitamin B12 is crucial in preventing possible irreversible neurologic damage, megaloblastic anemia, and failure to thrive. We assess the usefulness of the early detection of asymptomatic B12 deficiency related to acquired conditions and highlight the importance of monitoring serum vitamin B12 levels during pregnancy. We describe demographic, clinical, dietary, and biochemical data, including the evolution of a vitamin B12 deficiency's functional biomarkers. We enrolled 12 newborns (5 males) with an age range of 1-2 months old that were exclusively breastfed and asymptomatic. These cases were referred to our metabolic unit due to alterations in expanded newborn screening: high levels of methylmalonic acid and/or total homocysteine (tHcy). All mothers were under a vegetarian diet except three who had abnormal B12 absorption, and all presented low or borderline serum B12 level and high plasma levels of tHcy. Supplementation with oral vitB12 re-established the metabolic homeostasis of the mothers. In infants, therapy with an intramuscular injection of 1.0 mg hydroxocobalamin led to the rapid normalization of the metabolic pattern, and a healthy outcome was observed. Acquired B12 deficiency should be ruled out before proceeding in a differential diagnosis of cobalamin metabolism deficits, methylmalonic acidemia, and homocystinuria. info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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