Conditional survival and hazards of death for peripheral T-cell lymphomas
Autor: | Yuqin Song, Hongye Gao, Jun Zhu, Xiaopei Wang, Lan Mi, Weiping Liu, Xinqiang Ji, Xin Liu |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male Oncology Aging medicine.medical_specialty Anaplastic Lymphoma Antineoplastic Agents lymphoma Lower risk survival analysis International Prognostic Index T-cell Internal medicine medicine Humans T-cell lymphoma Anthracyclines peripheral Survival analysis Retrospective Studies business.industry Not Otherwise Specified Hazard ratio Lymphoma T-Cell Peripheral Cell Biology Middle Aged Prognosis medicine.disease Lymphoma Survival Rate Female business Research Paper |
Zdroj: | Aging (Albany NY) |
ISSN: | 1945-4589 |
Popis: | Typically, peripheral T-cell lymphoma (PTCLs) prognosis is estimated using overall survival before treatment. However, these estimates cannot show how prognosis evolves with the changing hazard rate over time. Patients (n = 650) with newly diagnosed PTCLs were enrolled retrospectively. After a median follow-up of 5.4 years, angioimmunoblastic T-cell lymphoma, peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) and NK/T cell lymphoma had initially lower 3-year conditional overall survival (COS3; i.e., the 3-year conditional overall survival was defined as the probability of surviving an additional 3 years) and higher hazards of death (26–44.3%). However, after 2 years, the COS3 increased and the death risk decreased over time, whereas anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma constantly had a lower risk over time (0–19.5%). For patients with complete remission after initial treatment, prognosis varied by histological subtypes, with PTCL, NOS having a negative impact. Our data suggested that the risk stratification using the International Prognostic Index might not accurately predict the COS3 for survivors of PTCLs. The COS3 provided time-dependent prognostic information for PTCLs, representing a possible surrogate prognosis indicator for long-term survivors after systemic chemotherapy. |
Databáze: | OpenAIRE |
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