Clinical pharmacology of progestins
| Autor: | Stefano Lello, Giovanni Scambia, Anna Capozzi |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Endometriosis Luteal phase Bioinformatics law.invention Pregnancy law medicine Humans Pharmacokinetics Progesterone Pharmacology Clinical pharmacology Progesterone Congeners business.industry Obstetrics and Gynecology Medical practice Uterine bleeding Estrogens Hormone replacement therapy (menopause) medicine.disease Menopause Settore MED/40 - GINECOLOGIA E OSTETRICIA Contraception Female Progestins business Progestin hormones hormone substitutes and hormone antagonists |
| Zdroj: | Minerva Obstetrics and Gynecology. 74 |
| ISSN: | 2724-6450 2724-606X |
| DOI: | 10.23736/s2724-606x.21.04881-8 |
| Popis: | Introduction In this paper, we report general pharmacological profile and major biological activities of natural progesterone (P) and progestins. The aim of this article consists of synthesizing the principal aspects of pharmacology and metabolism of P and progestins related to the clinical consequences of their use. Methods We review scientific literature on the topic "Progestins", evaluating the most relevant data from original articles, reviews and meta-analyses. Evidence synthesis Progestins represent a specific class of synthetic analogues of P clinically employed (alone or associated with estrogens) to manage several gynaecological conditions, for instance multiple abortions, luteal phase defect, premenstrual syndrome, abnormal uterine bleeding, endometriosis and menopause (for hormone replacement therapy). Besides their use in the field of contraception, many non-contraceptive benefits of estroprogestins are mostly due to the activities of progestins. Pharmacological characteristics, dosage and individual metabolism could be listed among the principal aspects influencing their clinical effects. Conclusions The choice of each progestin according to its pharmacological profile is crucial for the appropriate management of any gynaecological condition. An aware knowledge of these compounds is fundamental to hone medical practice. |
| Databáze: | OpenAIRE |
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