NTF-RINT, a new method for the epidemiological surveillance of MDR Mycobacterium tuberculosis L2/Beijing strains

Autor: Bernice J. Klotoe, Stefan Panaiotov, Guislaine Refrégier, Richard M. Anthony, Barry N. Kreiswirth, Natalia Kurepina, Elena Zholdibayeva, Christophe Sola
Přispěvatelé: Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Infection Génétique Evolution des Pathogènes Emergents (IGEPE), Département Microbiologie (Dpt Microbio), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Microbiology (medical)
DNA
Bacterial
Tuberculosis
Genotype
[SDV]Life Sciences [q-bio]
030106 microbiology
Immunology
DNA Mutational Analysis
Locus (genetics)
MDR-TB
Microbiology
Polymerase Chain Reaction
Mycobacterium tuberculosis
03 medical and health sciences
Predictive Value of Tests
Drug Resistance
Multiple
Bacterial
Tuberculosis
Multidrug-Resistant
medicine
Humans
Typing
Insertion sequence
Bacteriological Techniques
Molecular epidemiology
biology
Virulence
Isoniazid
High-Throughput Nucleotide Sequencing
Reproducibility of Results
biology.organism_classification
medicine.disease
bacterial infections and mycoses
Virology
Kazakhstan
3. Good health
Typical Beijing
Atypical Beijing
030104 developmental biology
Infectious Diseases
Phenotype
Population Surveillance
Mutation
DNA Transposable Elements
New York City
Rifampicin
medicine.drug
Zdroj: Tuberculosis
Tuberculosis, Elsevier, 2020, 120, pp.101894. ⟨10.1016/j.tube.2019.101894⟩
Tuberculosis, 2020, 120, pp.101894. ⟨10.1016/j.tube.2019.101894⟩
ISSN: 1472-9792
Popis: The most widely discussed antibiotic-resistant tuberculosis strains ("W" and "B0/W148", "CAO") belong to L2/Beijing Lineage and are characterized by IS6110 insertion sequences at the NTF locus. We present a high-throughput, microbead-based method, called NTF-RINT for detection of IS in NTF and Rifampicin and Isoniazid Typing. This method provides tuberculosis diagnostic confirmation, screens for the so-called modern L2/Beijing sublineage and detects mutations involved in resistance to Rifampicin (RIF) and Isoniazid (INH).
Databáze: OpenAIRE
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