NTF-RINT, a new method for the epidemiological surveillance of MDR Mycobacterium tuberculosis L2/Beijing strains
Autor: | Bernice J. Klotoe, Stefan Panaiotov, Guislaine Refrégier, Richard M. Anthony, Barry N. Kreiswirth, Natalia Kurepina, Elena Zholdibayeva, Christophe Sola |
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Přispěvatelé: | Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Infection Génétique Evolution des Pathogènes Emergents (IGEPE), Département Microbiologie (Dpt Microbio), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Microbiology (medical) DNA Bacterial Tuberculosis Genotype [SDV]Life Sciences [q-bio] 030106 microbiology Immunology DNA Mutational Analysis Locus (genetics) MDR-TB Microbiology Polymerase Chain Reaction Mycobacterium tuberculosis 03 medical and health sciences Predictive Value of Tests Drug Resistance Multiple Bacterial Tuberculosis Multidrug-Resistant medicine Humans Typing Insertion sequence Bacteriological Techniques Molecular epidemiology biology Virulence Isoniazid High-Throughput Nucleotide Sequencing Reproducibility of Results biology.organism_classification medicine.disease bacterial infections and mycoses Virology Kazakhstan 3. Good health Typical Beijing Atypical Beijing 030104 developmental biology Infectious Diseases Phenotype Population Surveillance Mutation DNA Transposable Elements New York City Rifampicin medicine.drug |
Zdroj: | Tuberculosis Tuberculosis, Elsevier, 2020, 120, pp.101894. ⟨10.1016/j.tube.2019.101894⟩ Tuberculosis, 2020, 120, pp.101894. ⟨10.1016/j.tube.2019.101894⟩ |
ISSN: | 1472-9792 |
Popis: | The most widely discussed antibiotic-resistant tuberculosis strains ("W" and "B0/W148", "CAO") belong to L2/Beijing Lineage and are characterized by IS6110 insertion sequences at the NTF locus. We present a high-throughput, microbead-based method, called NTF-RINT for detection of IS in NTF and Rifampicin and Isoniazid Typing. This method provides tuberculosis diagnostic confirmation, screens for the so-called modern L2/Beijing sublineage and detects mutations involved in resistance to Rifampicin (RIF) and Isoniazid (INH). |
Databáze: | OpenAIRE |
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