Update: Clinical Use of Plasma Lactate
| Autor: | Dez Hughes, Patricia G. Rosenstein, Íde Gillespie |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Bioenergetics 040301 veterinary sciences 0403 veterinary science Sepsis 03 medical and health sciences Dogs 0302 clinical medicine Disease severity Reference Values Intensive care Animals Humans Hyperlactatemia Medicine Dog Diseases Lactic Acid Small Animals Intensive care medicine Acidosis business.industry Septic shock 030208 emergency & critical care medicine 04 agricultural and veterinary sciences Hypoxia (medical) Prognosis medicine.disease medicine.symptom business |
| Zdroj: | Veterinary Clinics of North America: Small Animal Practice. 47:325-342 |
| ISSN: | 0195-5616 |
| Popis: | Lactate is an essential, versatile metabolic fuel in cellular bioenergetics. In human emergency and critical care, lactate is used as a biomarker and therapeutic endpoint and evidence is growing in veterinary medicine supporting its clinical utility. Lactate production is a protective response providing ongoing cellular energy during tissue hypoperfusion or hypoxia and mitigating acidosis. Hence, hyperlactatemia is closely associated with disease severity but it is an epiphenomenon as the body attempts to protect itself. This article reviews lactate biochemistry, kinetics, pathophysiology, some practical aspects of measuring lactate, as well as its use in diagnosis, prognosis, and monitoring. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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