A Novel Artificial Pancreas: Energy Efficient Valveless Piezoelectric Actuated Closed-Loop Insulin Pump for T1DM
| Autor: | Yigit Tascioglu, Alp Kaçar, Mehmet Bülent Özer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Insulin pump
Multiphysics Chemistry Multidisciplinary Nozzle PID controller Engineering Multidisciplinary 030209 endocrinology & metabolism Materials Science Multidisciplinary 02 engineering and technology lcsh:Technology valveless micropump Artificial pancreas Diffuser (thermodynamics) Physics Applied lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Control theory piezo-fluid-structural coupled simulation General Materials Science MATLAB lcsh:QH301-705.5 Instrumentation computer.programming_language Fluid Flow and Transfer Processes lcsh:T Process Chemistry and Technology General Engineering 021001 nanoscience & nanotechnology lcsh:QC1-999 Finite element method Computer Science Applications lcsh:Biology (General) lcsh:QD1-999 lcsh:TA1-2040 lcsh:Engineering (General). Civil engineering (General) closed-loop insulin pump 0210 nano-technology computer lcsh:Physics APS |
| Zdroj: | Applied Sciences Volume 10 Issue 15 Applied Sciences, Vol 10, Iss 5294, p 5294 (2020) |
| Popis: | The objective of this work is to develop a closed-loop controlled insulin pump to keep the blood glucose level of Type 1 diabetes mellitus (T1DM) patients in the desired range. In contrast to the existing artificial pancreas systems with syringe pumps, an energy-efficient, valveless piezoelectric pump is designed and simulated with different types of controllers and glucose-insulin models. COMSOL Multiphysics is used for piezoelectric-fluid-structural coupled 3D finite element simulations of the pump. Then, a reduced-order model (ROM) is simulated in MATLAB/Simulink together with optimal and proportional-integral-derivative (PID) controllers and glucose&ndash insulin models of Ackerman, Bergman, and Sorensen. Divergence angle, nozzle/diffuser diameters, lengths, chamber height, excitation voltage, and frequency are optimized with dimensional constraints to achieve a high net flow rate and low power consumption. A prototype is manufactured and experimented with different excitation frequencies. It is shown that the proposed system successfully controls the delivered insulin for all three glucose&ndash insulin models. |
| Databáze: | OpenAIRE |
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