The incudostapedial articulation in Down's syndrome (trisomy 21): a temporal bone study
| Autor: | Collin S. Karmody, Patricia Barcelos Ogando, Christof Röösli, Clarinda Northrop |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Hearing loss Hearing Loss Conductive Corrective surgery Incus Temporal bone medicine Humans Child Aged business.industry Infant Temporal Bone Down's syndrome - trisomy 21 Middle Aged medicine.disease Sensory Systems Stapes Conductive hearing loss Otorhinolaryngology Child Preschool Incudostapedial articulation Histopathology Female Neurology (clinical) Radiology medicine.symptom Down Syndrome business Trisomy |
| Zdroj: | Otologyneurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 34(8) |
| ISSN: | 1537-4505 |
| Popis: | Hypothesis Anomaly in the incudostapedial articulation (IS) may be responsible for persistent conductive hearing loss (HL) in Down's syndrome (DS) patients. Our goal was to perform a detailed histopathologic assessment of the role of the IS joint in the conductive HL. Background In addition to other disabilities, 38% to 78% of patients with Down's syndrome (Trisomy 21) have CHL, some of which are persistent despite maximum treatment. The cause of the persistent conductive HL remains unclear. Methods Retrospective analysis of temporal bone histopathology. Analyses of the midsection through the IS joint of 21 temporal bones (13 subjects) patients with DS and 31 temporal bones (18 subjects) from healthy subjects, performed by 2 blinded authors. The length of 7 different parameters of the width of the IS joint was measured and compared between the 2 groups. Results The IS joint of patients with DS was significantly wider than the normal control. As opposed to the control, it did not decrease because of age. Conclusion The persistent conductive HL in some patients with DS might be caused by anomaly of the IS joint. In severe cases, corrective surgery should be considered. |
| Databáze: | OpenAIRE |
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