Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria
| Autor: | Atanas G. Atanasov, Anake Kijjoa, John N. A. Hooper, Ali Al-Mourabit, Amr El-Demerdash, Mohamed A Tammam |
|---|---|
| Přispěvatelé: | Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Division of Immunopathology, University of Bern, CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
guanidine alkaloids
natural product crambescidin derivative Review [CHIM.THER]Chemical Sciences/Medicinal Chemistry 01 natural sciences n hydroxymethylisocystodamine Drug Discovery lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) ComputingMilieux_MISCELLANEOUS Molecular Structure macrolides Ecology [CHIM.ORGA]Chemical Sciences/Organic chemistry drug cytotoxicity biemnadin antiviral activity biological product steroids Marine sponges araiosamine C ptilocaulin derivative araiosamine B araiosamine D mirabilin A 8 9 dihydro 11 hydroxyascididemin pteridine derivative mirabilin F biological activity mirabilin B chemistry fatty acids mirabilin C mirabilin D mirabilin E crambescidins indole alkaloids unindexed drug physical chemistry marine sponges human araiosamine A Natural product batzelladine derivative 010405 organic chemistry Poecilosclerida antifungal activity Biemnida Biological product 0104 chemical sciences Sponge drug structure clathrynamide A clathrynamide C clathrynamide B chemical analysis chemical structure Mycale sponge (Porifera) Literature survey Clathria Aquatic Organisms Range (biology) [SDV]Life Sciences [q-bio] mycalazal derivative Pharmaceutical Science thiopepetides drug research chemistry.chemical_compound antibacterial activity terpenoids animal mass spectrometry mycalazol derivative batzelladines biology guanidine derivative netamine M ecionine A [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences mass fragmentography unclassified drug Porifera pyrrole-containing alkaloids neolabuaninen A polyketides drug isolation Mycale (Arenochalina) Biemna antineoplastic activity pteridine alkaloids cyclopeptide drug classification aquatic species Animals [CHIM]Chemical Sciences 14. Life underwater nuclear magnetic resonance spectroscopy Biological Products nonhuman isolation and purification Biemna biology.organism_classification alkaloid nucleotides 010404 medicinal & biomolecular chemistry lcsh:Biology (General) metabolism |
| Zdroj: | Marine drugs Marine drugs, MDPI, 2018, 16 (6), pp.214. ⟨10.3390/md16060214⟩ Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Marine Drugs, Vol 16, Iss 6, p 214 (2018) Marine Drugs |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md16060214⟩ |
| Popis: | Over the past seven decades, particularly since the discovery of the first marine-derived nucleosides, spongothymidine and spongouridine, from the Caribbean sponge Cryptotethya crypta in the early 1950s, marine natural products have emerged as unique, renewable and yet under-investigated pools for discovery of new drug leads with distinct structural features, and myriad interesting biological activities. Marine sponges are the most primitive and simplest multicellular animals, with approximately 8900 known described species, although more than 15,000 species are thought to exist worldwide today. These marine organisms potentially represent the richest pipeline for novel drug leads. Mycale (Arenochalina) and Clathria are recognized marine sponge genera belonging to the order Poecilosclerida, whereas Biemna was more recently reclassified, based on molecular genetics, as a new order Biemnida. Together, these sponge genera contribute to the production of physiologically active molecular entities with diverse structural features and a wide range of medicinal and therapeutic potentialities. In this review, we provide a comprehensive insight and up-to-date literature survey over the period of 1976–2018, focusing on the chemistry of the isolated compounds from members of these three genera, as well as their biological and pharmacological activities, whenever available. © 2018 by the authors. Acknowledgments: This work was supported by the mission sector of the Ministry of High Education of the Arab Republic of Egypt (Egyptian cultural bureau in Paris and Athens); Amr El-Demerdash’s, and Mohamed Tammam’s joint supervision were fully funded and supported. |
| Databáze: | OpenAIRE |
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