| Autor: |
Gayane Manukyan, Eva Kriegova, Ludek Slavik, Zuzana Mikulkova, Jana Ulehlova, Anush Martirosyan, Tomas Papajik |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Reproductive Immunology. 155:103791 |
| ISSN: |
0165-0378 |
| Popis: |
Antiphospholipid syndrome (APS) is an autoimmune thrombophilia that is characterised by thrombosis and obstetric complications in the presence of antiphospholipid antibodies (aPL). Pregnancy complications remain a challenging problem for patients with APS, especially during the first trimester. Although natural killer (NK) cells constitute up to 70% of decidual lymphocytes during the first trimester, their contribution to early pregnancy loss in APS is largely unknown. We aimed to analyse whether aPL are able to recruit antibody-dependent cellular cytotoxicity (ADCC) of NK cells, with special emphasis on the differences in the effects of aPL containing anti-β2GPI domain 1 (anti-β2GPI-D1) antibodies (aPL+/D1+) and those that do not (aPL+/D1-). Our findings revealed a differential distribution of NK subsets in the presence of different aPL. Namely, aPL+/D1- IgGs increased CD56 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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