| Autor: |
Vito Emanuele Catania, Giulia Malaguarnera, Gaetano Bertino, Laura Maria Chisari, Maria Castorina, Claudia Bonfiglio, Omar Cauli, Michele Malaguarnera |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Current pharmaceutical design. 28(38) |
| ISSN: |
1873-4286 |
| Popis: |
Background: The elderly is characterized by a gradual decline in body function, which represents the clinical situation called "frailty". Prefrailty is the intermediate stage between frailty and the robust condition. L-carnitine (LC) plays an important role in energy production from long-chain fatty acids in mitochondria and its serum level is lower in prefrail and frail subjects. Objective: This study aims to evaluate the effect of Acetyl-L-carnitine (ALCAR) in pre frail older patients. Methods: We scheduled 3 months of treatment and then 3 months of follow-up. 92 subjects were selected from May 2009 to July 2017 in a randomized, observational, double-blind, placebo-controlled study. We scheduled 3 months of treatment and then 3 months of follow-up. ALCAR (oral 1.5 g/bis in die - BID) or placebo group. Results: After the treatment, only the treated group displayed a decrease in C reactive protein (CRP) p Conclusions: ALCAR treatment delays the incidence and severity of onset in prefrail subjects of degenerative disorders of the elderly, with improvement in memory and cognitive processes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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