Serotonin and noradrenaline modulate chronic itch processing in mice
| Autor: | Hideki Funahashi, Yu Miyahara, Chiyo Muroi, Ayaka Haruta-Tsukamoto, Rumi Naono-Nakayama, Toshikazu Nishimori, Yoichiro Kogoh, Yasushi Ishida |
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| Rok vydání: | 2020 |
| Předmět: |
Central Nervous System
Male 0301 basic medicine Adrenergic Antagonists Serotonin Serotonin reuptake inhibitor Mirtazapine Fluvoxamine Pharmacology Noradrenergic and specific serotonergic antidepressant Norepinephrine 03 medical and health sciences 0302 clinical medicine Animals Medicine Serotonin receptor antagonist Serotonin and Noradrenaline Reuptake Inhibitors skin and connective tissue diseases Injections Spinal 5-HT receptor Adrenergic Uptake Inhibitors Behavior Animal business.industry Pruritus Antipruritics Nisoxetine Mice Inbred C57BL Disease Models Animal 030104 developmental biology Chronic Disease Serotonin Antagonists business Selective Serotonin Reuptake Inhibitors 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Journal of Pharmacology. 883:173319 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2020.173319 |
| Popis: | The roles of serotonin and noradrenaline in the modulation of chronic pruriceptive processing currently remain unclear. To clarify the contribution of serotonin and noradrenaline to chronic itch, the effects of the administration of antidepressants or noradrenaline reuptake inhibitors were evaluated in the present study. A pretreatment with milnacipran, a serotonin and noradrenaline reuptake inhibitor, and mirtazapine, a noradrenergic and specific serotonergic antidepressant, attenuated the induction of spontaneous scratching behavior in mice with chronic itch. The administration of a serotonin reuptake inhibitor, such as fluvoxamine and paroxetine, but not escitalopram, or a noradrenaline reuptake inhibitor, such as atomoxetine and nisoxetine, ameliorated the induction of spontaneous scratching behavior in mice with chronic itch. Furthermore, this attenuation was reversed by the administration of yohimbine, a selective α2-adrenoceptor antagonist, or methysergide, a non-selective serotonin receptor antagonist. These results suggest that elevated serotonin and noradrenaline levels are involved in the attenuation of scratching behavior induced by chronic itch, and serotonin receptors and an α2-adrenoceptor play a crucial role in chronic pruriceptive processing. |
| Databáze: | OpenAIRE |
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