Robust Treatment Planning in Intrafraction Motion Using TomoDirect™ Intensity-modulated Radiotherapy for Breast Cancer
| Autor: | Koichi Tokuue, Hideyuki Hongo, Misato Mase, Takeji Sakae, Motoko Omura |
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| Rok vydání: | 2021 |
| Předmět: |
Organs at Risk
Pharmacology Cancer Research business.industry Radiotherapy Planning Computer-Assisted medicine.medical_treatment Planning target volume Breast Neoplasms Radiotherapy Dosage medicine.disease General Biochemistry Genetics and Molecular Biology Radiation therapy Breast cancer Normal lung Intrafraction motion medicine Humans Female Lung volumes Radiotherapy Intensity-Modulated Intensity modulated radiotherapy Nuclear medicine business Radiation treatment planning Research Article |
| Zdroj: | In Vivo |
| ISSN: | 1791-7549 0258-851X |
| Popis: | Background/aim To evaluate the robustness of radiotherapy treatment planning optimization for respiratory-moving breast cancer using fixed-angle beams planning TomoDirect™ intensity-modulated radiotherapy (IMRT). Materials and methods A minimax optimisation algorithm was applied to 10 breast cancer patients. Two sets of treatment plans with or without robust techniques were prepared considering anterior-posterior and head-tail movements due to respiration. Parameters were compared between treatment plans: 95% planned target volume (PTV) dose, conformal index and homogeneity index (HI), and organs at risk (OAR) parameters including the lung volume receiving 20 Gy or more (V20) and 5 Gy (V5). Results Robust planning significantly improved parameters of 95% PTV dose and HI, without deteriorating V20 or V5 in the anterior-posterior movement, while it slightly improved 95% PTV and slightly deteriorated V20 in the head-tail movement. Conclusion Robust treatment planning improves coverage of targets moving because of respiration in the treatment of breast cancer using TomoDirect; however, normal lung doses should be cautiously evaluated on a case-by-case basis. |
| Databáze: | OpenAIRE |
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