Estrogen therapy increases plasma concentrations of nitric oxide metabolites in postmenopausal women but increases flow-mediated vasodilation only in younger women
| Autor: | Gautam Chaudhuri, Alberto Pardo, Luis Alfonso Díaz, Patricio Lopez-Jaramillo, Hermes Jaimes, Gustavo Parra |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Aging
medicine.medical_specialty Brachial Artery Population Placebo Nitric oxide chemistry.chemical_compound Double-Blind Method Reference Values Internal medicine Blood plasma Humans Medicine Nitrite education Nitrites Aged education.field_of_study Cross-Over Studies Estrogens Conjugated (USP) Nitrates medicine.diagnostic_test business.industry Obstetrics and Gynecology Middle Aged medicine.disease Postmenopause Vasodilation Menopause Endocrinology Reproductive Medicine chemistry Regional Blood Flow Female business Lipid profile Flow-Mediated Vasodilation |
| Zdroj: | Fertility and Sterility. 82:1550-1555 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2004.05.083 |
| Popis: | Objective To evaluate the effect of estrogen therapy (ET) on endothelial nitric oxide (NO) production and in flow-mediated vasodilation (FMV). Design Randomized, crossover, double-blind, placebo-controlled study. Setting Healthy postmenopausal women in an academic research environment. Patient(s) Forty postmenopausal women between 45 and 72 years of age. Intervention(s) Women received ET or placebo during two periods of 12 weeks that were separated by 2 weeks of washout. Main outcome measure(s) Flow-mediated vasodilation, nitrite and nitrate, lipid profile, creatinine, and glucose were measured at weeks 12 and 24. Student's t or Wilcoxon tests were used for comparative analyses, and κ test and limit analysis determined variability. Result(s) After placebo treatment, nitrate and nitrite mean concentration was 8.28 ± 1.17 mmol/L; it increased to 62.6 ± 12.82 mmol/L after ET. Percentage FMV was 18.8 ± 2.58 after the placebo period and did not change after ET (20.1 ± 1.92) in the whole sample, but in the subgroup (n = 15) of younger women (45–50 years of age), percentage FMV increased from 13.6 ± 3.6 after the placebo period to 22.2 ± 3.5 after ET. Conclusion(s) An increase in plasma concentrations of nitrite and nitrate after ET was observed in all the women studied, but the improvement in FMV was observed only in the younger ones. These age-related differences in FMV in response to ET must be further investigated. |
| Databáze: | OpenAIRE |
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