Extracorporeal photochemotherapy in progressive systemic sclerosis: a follow-up study
| Autor: | Joselyn Gonzalez, Joseph Schwartz, Albert S. Klainer, Mark Palangio, Emil Bisaccia |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Systemic disease medicine.medical_treatment Dermatology Kidney Kidney Function Tests Scleroderma Pulmonary function testing Photopheresis Surveys and Questionnaires Immunopathology medicine Humans Range of Motion Articular Lung Skin Autoimmune disease Scleroderma Systemic business.industry Middle Aged medicine.disease Dysphagia Connective tissue disease Respiratory Function Tests Surgery Treatment Outcome Female Joints medicine.symptom business Follow-Up Studies |
| Zdroj: | International Journal of Dermatology. 36:380-385 |
| ISSN: | 1365-4632 0011-9059 |
| DOI: | 10.1046/j.1365-4362.1997.00066.x |
| Popis: | Background Extracorporeal photochemotherapy (photopheresis), an immune-modulating therapy, has been demonstrated to elicit a therapeutic response in the treatment of several autoimmune disorders. We evaluated the use of photopheresis in the treatment of patients with progressive systemic sclerosis (PSS; scleroderma). Methods Five patients with early-onset, diffuse PSS were treated with photopheresis on 2 successive days monthly for an average of 59 months (range 54–69 months). We initially reported the response this group of patients had to photopheresis treatment at an average of 11 months (range 6–21 months). Results An improvement or stabilization was noted in most patients in skin thickening, joint mobility, pulmonary function studies, oral aperture, functional index, as well as symptoms including Raynaud's phenomenon, dyspnea, fatigue, dysphagia, arthralgias, and cutaneous ulcers. Renal function tests remained within normal range. A total of 296 monthly treatments were administered without significant toxicity. Conclusions This study suggests that extended use of extracorporeal photochemotherapy in the management of early-onset, diffuse PSS is well tolerated and may provide an increasingly beneficial clinical outcome. |
| Databáze: | OpenAIRE |
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