Gender differences in a mouse model of chemotherapy-induced neuropathic pain
| Autor: | Leila Safaeian, Naji-Esfahani H, Alireza Abed, Golnaz Vaseghi, Mahmoud Rafieian-Kopaei, Pilehvarian Aa |
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| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine Paclitaxel medicine.medical_treatment Intraperitoneal injection Antineoplastic Agents Mice 03 medical and health sciences chemistry.chemical_compound Sex Factors 0302 clinical medicine medicine Animals Cisplatin Chemotherapy General Veterinary business.industry medicine.disease Antineoplastic Agents Phytogenic Disease Models Animal 030104 developmental biology Allodynia chemistry Anesthesia Neuropathic pain Neuralgia Female Animal Science and Zoology medicine.symptom Licking business Injections Intraperitoneal 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Laboratory Animals. 50:15-20 |
| ISSN: | 1758-1117 0023-6772 |
| DOI: | 10.1177/0023677215575863 |
| Popis: | Chemotherapy-induced neuropathic pain is one of the major problems for cancer patients. Although paclitaxel and cisplatin are widely used in women, most laboratory studies of chemotherapy-induced neuropathic pain have been conducted on male animals. The current study examined the gender differences in chemotherapy-induced neuropathic pain in mice. Neuropathic pain was induced by intraperitoneal injection of paclitaxel (2 mg/kg) for five consecutive days and cisplatin (1 mg/kg) for seven consecutive days. Cold allodynia was evaluated by measuring the paw withdrawal frequency and duration of paw licking in mice; however, mechanical allodynia was assessed by von Frey filaments. Neuropathic pain began to manifest after a few days ( P |
| Databáze: | OpenAIRE |
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