Abnormal cervical cytology among HIV-positive women in Nigeria
| Autor: | Preye O. Fiebai, Boma P. Athanasius, Israel Jeremiah, Goddy Bassey, JI Ikimalo |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Study groups medicine.medical_specialty Adolescent Bethesda system Human immunodeficiency virus (HIV) Nigeria Uterine Cervical Neoplasms Disease medicine.disease_cause Teaching hospital Young Adult Abnormal cervical smears HIV Seropositivity Prevalence medicine Humans Prospective Studies Vaginal Smears Gynecology medicine.diagnostic_test business.industry Obstetrics Age Factors Obstetrics and Gynecology General Medicine Middle Aged Uterine Cervical Dysplasia CD4 Lymphocyte Count Cross-Sectional Studies Abnormal cervical cytology Female Port harcourt business Precancerous Conditions Papanicolaou Test |
| Zdroj: | International Journal of Gynecology & Obstetrics. 125:103-106 |
| ISSN: | 0020-7292 |
| Popis: | To determine the prevalence of abnormal cervical smears and high-grade lesions among HIV-positive and HIV-negative women, and to assess the relationship between severity of disease and CD4 count.In a prospective cross-sectional comparative study, 250 HIV-positive and 250 HIV-negative women attending the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria, were enrolled between January and March 2012. Cervical smear samples were collected from participants, examined, and reported via the Bethesda system. Data management and analysis was done with SPSS. Differences between the 2 study groups were determined by χ2 test and Student t test.The prevalence of abnormal cervical smears was significantly higher among HIV-positive women (34.4%) than among HIV-negative women (20.2%) (P0.01). The proportion of high-grade lesions was significantly higher among HIV-positive women (23.5%) than among HIV-negative women (8.2%) (P=0.025). HIV-positive women with a CD4 count below 500 cells/mm3 had significantly more abnormal cervical smears (28.3%) compared with those with a CD4 count of 500 cells/mm3 or more (6.1%) (P=0.04).HIV-positive women were found to be at significantly greater risk of developing abnormal cervical cytology and high-grade lesions compared with HIV-negative women. |
| Databáze: | OpenAIRE |
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