Electrocardiographic evidence of abnormal atrial phenotype in Brugada syndrome
| Autor: | Alex Pui-Wai Lee, Ka Hou Christien Li, Tong Liu, Jasmine Chopra, George Bazoukis, Sharen Lee, Sunaina Reddy, Konstantinos P. Letsas, Sohaib Haseeb, Gary Tse |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
030204 cardiovascular system & hematology Electrocardiography 03 medical and health sciences 0302 clinical medicine Channelopathy Internal medicine Atrial Fibrillation medicine Humans Heart Atria cardiovascular diseases 030212 general & internal medicine Stroke Brugada Syndrome Retrospective Studies Brugada syndrome medicine.diagnostic_test business.industry fungi P wave Retrospective cohort study Atrial fibrillation medicine.disease Exact test Phenotype Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Electrocardiology. 55:102-106 |
| ISSN: | 0022-0736 |
| DOI: | 10.1016/j.jelectrocard.2019.05.005 |
| Popis: | Background Brugada syndrome (BrS) is an inherited ion channelopathy that may predispose affected individuals to atrial cardiomyopathy. We tested the hypothesis that BrS patients have higher degrees of atrial electrophysiological abnormalities compared to controls, and these can be reflected by changes in P-wave parameters determined on the electrocardiogram (ECG). Methods This was a single-center retrospective study comparing BrS patients to age- and gender-matched control subjects. Mean P-wave duration (PWDmean), maximum PWD (PWDmax) and minimum PWD (PWDmin), P-wave dispersion (PWDmax – PWDmin), and P-wave terminal force in V1 (PTFV1) were measured. PWDmax ≥ 120 ms, in the presence and absence of biphasic P-waves in the inferior leads, were termed advanced and partial inter-atrial block (IAB), respectively. Results The proportion of IAB was significantly higher in BrS patients (28/51; 55%) than in control subjects (14/51; 27%; Fisher's Exact test; P Conclusion Atrial conduction abnormalities are frequently observed in BrS. These patients may require monitoring for future development of atrial fibrillation and stroke. |
| Databáze: | OpenAIRE |
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