Palladium-Catalyzed Enantioselective Oxidation of Chiral Secondary Alcohols: Access to Both Enantiomeric Series
| Autor: | Raissa M. Trend, Cedric Genet, Matthew J. McGrath, Peter O'Brien, David C. Ebner, Brian M. Stoltz |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Chemistry
Enantioselective synthesis chemistry.chemical_element Total synthesis Stereoisomerism General Chemistry Crystallography X-Ray Isoquinolines Heterocyclic Compounds 4 or More Rings Catalysis Article Kinetic resolution chemistry.chemical_compound Diamine Alcohols Organic chemistry Enantiomer Selectivity Oxidation-Reduction Palladium |
| Popis: | Rapid resolution: A new catalyst system for the oxidative kinetic resolution of secondary alcohols leads to dramatic rate increases. This system allows the use of a diamine to provide access to either enantiomer of a range of alcohols with good selectivity factors (see scheme). This method has been applied to the formal total synthesis of (−)-amurensinine. |
| Databáze: | OpenAIRE |
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