Immunoglobulin kappa gene repertoire and somatic hypermutation patterns in follicular lymphoma
| Autor: | Vasilis Bikos, Niki Stavroyianni, Theodora Papadaki, Tatjana Smilevska, Αthanasios Fassas, Nikolaos Laoutaris, Achilles Αnagnostopoulos, Eugenia Tsakou, Anastasia Hadzidimitriou, Kostas Stamatopoulos, Chrysoula Belessi |
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| Rok vydání: | 2008 |
| Předmět: |
B-cell receptor
Follicular lymphoma Receptors Antigen B-Cell Somatic hypermutation medicine.disease_cause Immunoglobulin light chain Immunoglobulin kappa-Chains Germline mutation medicine Humans Lymphoma Follicular Molecular Biology B cell Gene Rearrangement B-Lymphocytes Mutation biology Cell Biology Hematology medicine.disease Molecular biology Clone Cells medicine.anatomical_structure biology.protein Molecular Medicine Somatic Hypermutation Immunoglobulin Antibody |
| Zdroj: | Blood Cells, Molecules, and Diseases. 41:215-218 |
| ISSN: | 1079-9796 |
| DOI: | 10.1016/j.bcmd.2008.06.002 |
| Popis: | Immunoglobulin kappa gene usage and somatic mutation patterns were studied in a series of 47 IGKV-J rearrangements amplified in 42 follicular lymphoma (FL) cases. The IGKV1-39/1D-39 gene predominated and was significantly over-represented compared to normal cells, autoreactive cells or other B cell lymphomas. The impact of somatic hypermutation varied significantly; nevertheless, mutation distribution patterns indicated pressure for preservation of the B cell receptor. In conclusion, the present series demonstrates biased usage of IGKV genes in FL and alludes to the important role of immunoglobulin kappa light chains in antigen selection of the clonogenic B cells in FL. |
| Databáze: | OpenAIRE |
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