Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation

Autor: Lakshmi Devi Kodidhela, Shivaranjani Vutharadhi, Umamaheswari Jolapuram
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Homocysteine
Anti-Inflammatory Agents
Apoptosis
030204 cardiovascular system & hematology
Pharmacology
chemistry.chemical_compound
0302 clinical medicine
Spinacia oleracea
Medicine
Gallic acid
Chromatography
High Pressure Liquid
biology
General Medicine
Biochemistry
Myeloperoxidase
Cytokines
Inflammation Mediators
medicine.symptom
Cardiomyopathies
Signal Transduction
Spinacia
medicine.drug_class
Inflammation
Anti-inflammatory
Necrosis
03 medical and health sciences
Nutraceutical
Gallic Acid
Animals
Rats
Wistar
Plants
Medicinal
Dose-Response Relationship
Drug
Plant Extracts
business.industry
Methanol
Myocardium
Isoproterenol
Paraoxonase
biology.organism_classification
Plant Leaves
Disease Models
Animal
030104 developmental biology
chemistry
Cytoprotection
Dietary Supplements
Solvents
biology.protein
business
Phytotherapy
Zdroj: Biomedicine & Pharmacotherapy. 85:239-247
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2016.10.103
Popis: Cardiovascular diseases (CVDs) remain the principal cause of death in both developed and developing countries. The present study was intended to appraise the nutraceutical inherent of HPLC standardized Spinacia oleracea methanolic leaf extract (SoLE) in isoproterenol (ISO) induced male albino Wistar rats via activation of pro-inflammatory signaling pathway that drives myocardial necrosis. Biochemical analysis of ISO injected rats showed significant alterations in the activities of homocysteine, paraoxonase, lecithin cholesterol acyltransferase, C-reactive protein, myeloperoxidase and caspase-3 which were further confirmed by the histopathological examination. In addition, it also flaunted a significant increase in pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6 in ISO administered rats when compared with normal control rats. Pretreatment with SoLE (100, 200, and 300mg/kg bw) along with positive control gallic acid, significantly prevented all the adverse effects in ISO administered rats in a dose dependent manner. These results also reiterated the expected amelioration of myocardial necrosis in ISO induced MI rats conveying anti-atherogenic, anti-apoptotic and anti-inflammatory activities of SoLE.
Databáze: OpenAIRE
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