Single photon emission computed tomography study of human cancer
| Autor: | D. SLOSMAN, D. TOWNSEND, B. POLLA, R. EGELI, P. AMBROSETTI, J. E. RYSER, M. FORNI, R. KAELIN, O. REVERDIN, T. ROCHAT, R. ROHNER, A. DONATH |
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| Rok vydání: | 1985 |
| Předmět: |
Male
Single-photon emission computed tomography Bleomycin Malignancy chemistry.chemical_compound Neoplasms Humans Medicine Radiology Nuclear Medicine and imaging Cobalt Radioisotopes Prospective cohort study Aged Cancer staging medicine.diagnostic_test business.industry Cancer Bayes Theorem General Medicine Middle Aged medicine.disease Diaphragm (structural system) chemistry Female Abnormality Nuclear medicine business Tomography Emission-Computed |
| Zdroj: | Nuclear Medicine Communications. 6:795-803 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-198512000-00008 |
| Popis: | The sensitivity and specificity of single photon emission tomography with 57Co-labelled bleomycin (57Co-BLM) for the detection of cancer was determined from a prospective study involving a large group of patients selected to investigate roentgenographic abnormalities. Eighty-four of the 104 patients studied had malignant disease, of whom 76 had a positive scintigram. Eighteen of the 20 patients with benign disorders had a negative scintigram. The sensitivity and specificity was therefore 90.5 and 90% respectively. For the subset of patients who underwent investigation below the diaphragm, the sensitivity was 85.7%, while for investigation above the diaphragm, it reached 95.2% (this excluded reconstructions on the bladder level, because it produced large artifacts). This study leads to the conclusion that SPECT can be used specifically to investigate unidentified X-ray abnormality and diagnose malignancy using 57Co-BLM. In addition, we propose further investigation to evaluate the usefulness of this method in staging cancer. |
| Databáze: | OpenAIRE |
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