Prospective Evaluation of Prostate Specific Antigen and Prostate Specific Antigen Density in the Detection of Carcinoma of the Prostate
| Autor: | Peter R. Carroll, Katsuto Shinohara, Vivek Bhargava, Joseph C. Presti, Regina M. Hovey |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test Receiver operating characteristic business.industry Urology Cancer Rectal examination urologic and male genital diseases medicine.disease Prostate-specific antigen medicine.anatomical_structure Prostate Biopsy medicine Carcinoma Adenocarcinoma business |
| Zdroj: | The Journal of Urology. :907-911 |
| ISSN: | 0022-5347 |
| DOI: | 10.1097/00005392-199703000-00045 |
| Popis: | Purpose: We evaluated prospectively the ethnic variations in prostate specific antigen (PSA) and prostate specific antigen density in the detection of carcinoma of the prostate.Materials and Methods: A total of 297 consecutive patients with an elevated serum PSA and/or abnormal digital rectal examination underwent transrectal ultrasound with lesion directed and systematic biopsy (6 if the prostatic volume was 50 cc or less and 12 if it was greater than 50 cc). Receiver operating characteristic curves, predictive values and likelihood ratios were calculated for PSA and PSA density for white and black patients. Ethnic analysis was performed for the entire group, patients with a normal digital rectal examination, and those with a normal digital rectal examination and PSA of 4 to 10 ng./ml.Results: Of the 297 patients 131 (44%) had cancer, including 48 of 97 black (50%) and 83 of 200 white (42%) patients. Median PSA, PSA density and prostate size did not differ between the positive or negative biopsy ... |
| Databáze: | OpenAIRE |
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