A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
| Autor: | Khaled El-Shami, Amar R. Jariwala, Hind Rafei, Aneesha Hossain |
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| Rok vydání: | 2017 |
| Předmět: |
Mutant
Wild type Hematology Biology lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease lcsh:RC254-282 Virology Article Pathogenesis 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Mutation (genetic algorithm) medicine Immunoglobulin heavy chain Hairy cell leukemia Cladribine IGHV@ 030215 immunology medicine.drug |
| Zdroj: | Leukemia Research Reports Leukemia Research Reports, Vol 7, Iss C, Pp 20-22 (2017) |
| ISSN: | 2213-0489 |
| DOI: | 10.1016/j.lrr.2017.01.001 |
| Popis: | The V600 BRAF mutation has been described as a key mutation in the pathogenesis of classical hairy cell leukemia (c-HCL) cases without expression of a mutant immunoglobulin heavy chain (IgHV). Here we present a rare case of c-HCL with neither V600 BRAF mutation nor the aforementioned IgHV variant successfully treated with cladribine and review the current literature on its use in women of childbearing age/pregnancy. Highlights • This is a rare case of BRAF V600 mutation negative c-HCL with wild-type IgHV. • Unlike mutant BRAF HCL, The prognosis of wild-type BRAF in c-HCL is unknown. • In our experience, initial response to cladribine is similar to V600 BRAF c-HCL. |
| Databáze: | OpenAIRE |
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