Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination
| Autor: | Teresa Limjoco, Toni Pacioles, Maria Tria Tirona, Ahmed Gamal Elsayed, Roma Srivastava |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Lower gastrointestinal bleeding Chemotherapy complications Paclitaxel Cyclophosphamide medicine.medical_treatment Case Report lcsh:RC254-282 Gastroenterology Ischemic colitis Carboplatin Descending colon 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Splenic flexure Chemotherapy business.industry lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease medicine.anatomical_structure Oncology chemistry 030220 oncology & carcinogenesis business 030215 immunology medicine.drug |
| Zdroj: | Case Reports in Oncology Case Reports in Oncology, Vol 10, Iss 2, Pp 689-693 (2017) |
| ISSN: | 1662-6575 |
| DOI: | 10.1159/000479226 |
| Popis: | A 62-year-old white female with a history of early-stage triple-negative breast cancer on a combination of carboplatin and paclitaxel in the adjuvant setting presented with lower gastrointestinal bleeding. She tolerated 4 cycles of dose-dense adriamycin/cyclophosphamide with no major symptoms. After 6 cycles of weekly paclitaxel in combination with carboplatin every 3 weeks, she presented with diarrhea and lower gastrointestinal bleeding. Colonosopic examination showed erythema and inflammation in the splenic flexure, descending colon, and sigmoid colon consistent with ischemic colitis. Pathology favored the same diagnosis. She was treated conservatively with intravenous fluids and bowel rest. Chemotherapy was held for 2 weeks and resumed after recovery without carboplatin. She was able to tolerate the remaining 6 cycles of paclitaxel with no recurrence of her symptoms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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