Subcellular localization of two neurotropic drugs in three varieties of central nervous system cells by secondary ion mass spectroscopy (SIMS) microscopy
| Autor: | L. Zhang, P. Galle, Berry Jp, Marcienne Tardy, F. Escaig |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Central Nervous System
Central nervous system Flunitrazepam Biology Mass Spectrometry Mice chemistry.chemical_compound Phenothiazine medicine Animals Molecule Cells Cultured Microscopy Triflupromazine Cell Biology General Medicine Subcellular localization Secondary ion mass spectrometry medicine.anatomical_structure Animals Newborn chemistry Biochemistry Cytoplasm Intracellular medicine.drug |
| Zdroj: | Biology of the Cell. 74:99-103 |
| ISSN: | 0248-4900 |
| Popis: | The intracellular localization of two neurotropic drugs, flunitrazepan (benzodiazepine) and triflupromazine (phenothiazine), was studied by secondary ion mass spectrometry microscopy (SIMS) in three varieties of cells. The images of the intracellular distributions of the two drugs are easily obtained by selecting the fluorine atom of the molecules. These images show that the drug from the benzodiazepine group is mainly located in the nuclei, whereas the phenothiazine is exclusively located inside the cytoplasm. |
| Databáze: | OpenAIRE |
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