Incident dysglycemia and progression to type 1 diabetes among participants in the Diabetes Prevention Trial-Type 1
| Autor: | Jeffrey P. Krischer, David Cuthbertson, Lisa Rafkin-Mervis, Jay M. Sosenko, Jerry P. Palmer, Jeffery Mahon, Carla J. Greenbaum, Jay S. Skyler, Catherine C. Cowie |
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| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Adolescent Endocrinology Diabetes and Metabolism Impaired glucose tolerance Insulin resistance Diabetes mellitus Internal medicine Glucose Intolerance Internal Medicine Medicine Humans Epidemiology/Health Services Research Child Proportional Hazards Models Original Research Advanced and Specialized Nursing Type 1 diabetes Glucose tolerance test medicine.diagnostic_test business.industry Proportional hazards model Incidence (epidemiology) nutritional and metabolic diseases Glucose Tolerance Test medicine.disease Impaired fasting glucose Endocrinology Diabetes Mellitus Type 1 Female business |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 |
| Popis: | OBJECTIVE We studied the incidence of dysglycemia and its prediction of the development of type 1 diabetes in islet cell autoantibody (ICA)-positive individuals. In addition, we assessed whether dysglycemia was sustained. RESEARCH DESIGN AND METHODS Participants (n = 515) in the Diabetes Prevention Trial–Type 1 (DPT-1) with normal glucose tolerance who underwent periodic oral glucose tolerance tests (OGTTs) were followed for incident dysglycemia (impaired fasting glucose, impaired glucose tolerance, and/or high glucose levels at intermediate time points of OGTTs). Incident dysglycemia at the 6-month visit was assessed for type 1 diabetes prediction. RESULTS Of 515 participants with a normal baseline OGTT, 310 (60%) had at least one episode of dysglycemia over a maximum follow-up of 7 years. Dysglycemia at the 6-month visit was highly predictive of the development of type 1 diabetes, both in those aged CONCLUSIONS ICA-positive individuals with normal glucose tolerance had a high incidence of dysglycemia. Incident dysglycemia in those who are ICA positive is strongly predictive of type 1 diabetes. Children with incident dysglycemia have an especially high risk. Fluctuations in and out of the dysglycemic state are not uncommon before the onset of type 1 diabetes. |
| Databáze: | OpenAIRE |
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