Preparation and Characterization of Vancomycin-Loaded Electrospun Rana chensinensis Skin Collagen/Poly(L-lactide) Nanofibers for Drug Delivery
| Autor: | Zhichao Zhang, Lihua Liu, Rui Zhang, Zhouyang Sun, Dahui Sun, Ziqi Li, Mei Zhang, Wendi Ma |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Article Subject technology industry and agriculture 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Contact angle Differential scanning calorimetry Chemical engineering Nanofiber Drug delivery lcsh:Technology (General) lcsh:T1-995 General Materials Science Fourier transform infrared spectroscopy Composite material Coaxial 0210 nano-technology Drug carrier Environmental scanning electron microscope |
| Zdroj: | Journal of Nanomaterials, Vol 2016 (2016) |
| ISSN: | 1687-4110 |
| DOI: | 10.1155/2016/9159364 |
| Popis: | Collagen was extracted from abandonedRana chensinensisskin in northeastern China via an acid enzymatic extraction method for the use of drug carriers. In this paper we demonstrated two different nanofiber-vancomycin (VCM) systems, that is, VCM blended nanofibers and core-shell nanofibers with VCM in the core.Rana chensinensisskin collagen (RCSC) and poly(L-lactide) (PLLA) (3 : 7) were blended in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) at a concentration of 10% (g/mL) to fabricate coaxial and blend nanofibers, respectively. Coaxial and blend electrospun RCSC/PLLA nanofibers containing VCM (5 wt%) were evaluated for the local and temporal delivery of VCM. The nanofiber scaffolds were characterized by environmental scanning electron microscope (ESEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FTIR), differential scanning calorimeter (DSC), water contact angle (WCA), and mechanical tests. The drug release of VCM in these two systems was compared by using UV spectrophotometer. The empirical result indicated that both the blend and coaxial RCSC/PLLA scaffolds followed sustained control release for a period of 80 hours, but the coaxial nanofiber might be a potential drug delivery material for its better mechanical properties and sustained release effect. |
| Databáze: | OpenAIRE |
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