The relationship between urine volume and drain volume as determinants of fractional urea clearance in continuous peritoneal dialysis
| Autor: | N Nicolopoulou, Batzili E, Kakavas J, Glen H. Murata, Antonios H. Tzamaloukas, Nicholas Dombros, S Voudiklari, Elias V. Balaskas, Dimitriadis A, Antoniou S |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Urine volume medicine.medical_treatment Body water Biomedical Engineering Biophysics Analytical chemistry Bioengineering Urinalysis Peritoneal dialysis Biomaterials chemistry.chemical_compound Predictive Value of Tests medicine Humans Urea Urinary volume Urea clearance Chemistry Reproducibility of Results General Medicine Predictive factor Surgery Kinetics Volume (thermodynamics) Feasibility Studies Peritoneal Dialysis |
| Zdroj: | ASAIO journal (American Society for Artificial Internal Organs : 1992). 42(6) |
| ISSN: | 1058-2916 |
| Popis: | A logistic regression model developed and validated in Albuquerque identified 24 hr urine volume (UV) and 24 hr drain volume/(body water) (DV/V) as predictors of fractional urea clearance (KT/V) in continuous peritoneal dialysis (CPD). Solution of this model provided DV/V values consistent with KT/V at least equal to a target KT/V for a given UV. The predictive accuracy of these unique DV/V values was tested in urea kinetic studies performed in 108 CPD patients in Thessaloniki and Athens with UV varying between 0 and 2 L/24 h. Two target weekly KT/V values, 1.70 and 1.90, were investigated. The equation DV/V = (5.2811-3.6996 UV)/ 17.554, derived by solving the logistic regression model, detected weekly KT/V1.70 (69/108, or 63.9% of the studies) with a sensitivity of 87.3% and a specificity of 60.4%. According to the same equation, the maximal UV consistent with weekly KT/Vor = 1.70 is 1.427 L/24 hr. The equation DV/V = (5.4994-2.6007 UV)/17.007 detected weekly KT/V1.90 (44/108, or 40.7% of the studies) with a sensitivity of 90.3% and a specificity of 79.2%. According to this equation, the maximal UV consistent with weekly KT/Vor = 1.90 is 2.115 L/24 hr. Determination of the lowest daily DV consistent with a target KT/V at any daily UV (within a wide range) is feasible in CPD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|