Clinical Characteristics and Antibiotic Resistance of Mycoplasma Pneumoniae Pneumonia in Hospitalized Chinese Children
| Autor: | Ling Wang, Jia-Hui Pan, Chen Yuan, Hong-Zhou Ye, Gang Li, Yan-Ping Xie, Fang-Mei Min, Yin-Jie Ling |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Mycoplasma pneumoniae medicine.medical_specialty China medicine.drug_class 030106 microbiology Cephalosporin Antibiotics Erythromycin Enzyme-Linked Immunosorbent Assay Microbial Sensitivity Tests Azithromycin medicine.disease_cause Throat culture 03 medical and health sciences Structure-Activity Relationship 0302 clinical medicine Antibiotic resistance Internal medicine Drug Discovery Drug Resistance Bacterial Pneumonia Mycoplasma medicine Humans 030212 general & internal medicine Child medicine.diagnostic_test Dose-Response Relationship Drug business.industry Organic Chemistry General Medicine Computer Science Applications Anti-Bacterial Agents Penicillin Female business medicine.drug |
| Zdroj: | Combinatorial chemistryhigh throughput screening. 21(10) |
| ISSN: | 1875-5402 |
| Popis: | Aim: To analyze the clinical characteristics and antibiotic resistance of Mycoplasma pneumoniae pneumonia (MP) in Chinese patients, providing valuable information for the management of patients with MP. Methods: A total of 120 children who were hospitalized in The First Hospital of Huzhou between January and December 2016 for respiratory tract infection due to M. pneumoniae were enrolled in this study. Infection with M. pneumoniae was confirmed by ELISA for M. pneumoniae antibody, PCR, and throat culture. Antibiotic resistance was measured from the minimum inhibitory concentrations (MICs) of antibiotics. The 23S rRNA gene of M. pneumoniae was also examined for mutations using DNA sequencing. Patients with MP were classified into antibiotic resistance (n = 98) and no resistance (n = 20) groups. For the 98 patients showing antibiotic resistance, they were further stratified into subgroups based on the antibiotics initially prescribed: azithromycin or erythromycin (n = 78) and cephalosporin or penicillin (n = 20). Clinical characteristics were compared between the patient groups. Results: Antibiotic resistance group presented significantly longer febrile days compared to the no resistance group (P = 0.007). The number of febrile days after macrolide treatment was also longer in antibiotic resistance group than in no resistance group (P = 0.042). MP patients initially treated with azithromycin or erythromycin showed a longer average duration of respiratory symptoms (P = 0.046) and had a fever for more days after macrolide treatment (P = 0.009) compared to those received cephalosporin or penicillin. The average white blood cell count of patients treated with azithromycin or erythromycin was nearly half of those treated with cephalosporin or penicillin (P < 0.001). Nearly 90% of the resistant M. pneumoniae strains showed A to G substitution at position 2063 of the 23S rRNA gene. Conclusion: The clinical characteristics and antibiotic resistance of MP were analyzed in 120 Chinese patients. DNA sequencing revealed a highly prevalent A2063G mutation in the 23S rRNA gene. |
| Databáze: | OpenAIRE |
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