Radiation-Responsive Esculin-Derived Molecular Gels as Signal Enhancers for Optical Imaging
| Autor: | Julian R. Silverman, Nabendu B. Pramanik, Sai Sateesh Sagiri, George John, Jan Grimm, Qize Zhang, Travis M. Shaffer, Malick Samateh |
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| Rok vydání: | 2017 |
| Předmět: |
Photon
Materials science Nanotechnology 02 engineering and technology Cancer imaging Radiation 021001 nanoscience & nanotechnology Fluorescence Signal 030218 nuclear medicine & medical imaging Ionizing radiation 03 medical and health sciences 0302 clinical medicine Optical imaging Self-healing hydrogels General Materials Science 0210 nano-technology |
| Zdroj: | ACS Applied Materials & Interfaces. 9:43197-43204 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.7b15548 |
| Popis: | Recent interest in detecting visible photons that emanate from interactions of ionizing radiation (IR) with matter has spurred the development of multifunctional materials that amplify the optical signal from radiotracers. Tailored stimuli-responsive systems may be paired with diagnostic radionuclides to improve surgical guidance and aid in detecting therapeutic radionuclides otherwise difficult to image with conventional nuclear medicine approaches. Because light emanating from these interactions is typically low in intensity and blue-weighted (i.e., greatly scattered and absorbed in vivo), it is imperative to increase or shift the photon flux for improved detection. To address this challenge, a gel that is both scintillating and fluorescent is used to enhance the optical photon output in image mapping for cancer imaging. Tailoring biobased materials to synthesize thixotropic thermoreversible hydrogels (a minimum gelation concentration of 0.12 wt %) offers image-aiding systems which are not only functional but also potentially economical, safe, and environmentally friendly. These robust gels (0.66 wt %, ∼900 Pa) respond predictably to different types of IRs including β- and γ-emitters, resulting in a doubling of the detectable photon flux from these emitters. The synthesis and formulation of such a gel are explored with a focus on its physicochemical and mechanical properties, before being utilized to enhance the visible photon flux from a panel of radionuclides as detected. The possibility of developing a topical cream of this gel makes this system an attractive potential alternative to current techniques, and the multifunctionality of the gelator may serve to inspire future next-generation materials. |
| Databáze: | OpenAIRE |
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