Manipulation of Focal Adhesion Signaling by Pathogenic Microbes
| Autor: | Korinn N. Murphy, Amanda J Brinkworth |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Integrins Review Biology medicine.disease_cause Bacterial Physiological Phenomena Catalysis Inorganic Chemistry Focal adhesion Extracellular matrix lcsh:Chemistry 03 medical and health sciences stress fibers Bacterial Proteins medicine Animals Humans Secretion Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Actin integrin signaling Focal Adhesions vinculin mimetic 030102 biochemistry & molecular biology Bacteria Effector pathogenesis Organic Chemistry General Medicine Bacterial Infections Actin cytoskeleton Computer Science Applications Cell biology Extracellular Matrix Molecular mimicry 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Host-Pathogen Interactions outside–in signaling Intracellular Signal Transduction host–pathogen interactions |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 1358, p 1358 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Focal adhesions (FAs) serve as dynamic signaling hubs within the cell. They connect intracellular actin to the extracellular matrix (ECM) and respond to environmental cues. In doing so, these structures facilitate important processes such as cell–ECM adhesion and migration. Pathogenic microbes often modify the host cell actin cytoskeleton in their pursuit of an ideal replicative niche or during invasion to facilitate uptake. As actin-interfacing structures, FA dynamics are also intimately tied to actin cytoskeletal organization. Indeed, exploitation of FAs is another avenue by which pathogenic microbes ensure their uptake, survival and dissemination. This is often achieved through the secretion of effector proteins which target specific protein components within the FA. Molecular mimicry of the leucine–aspartic acid (LD) motif or vinculin-binding domains (VBDs) commonly found within FA proteins is a common microbial strategy. Other effectors may induce post-translational modifications to FA proteins through the regulation of phosphorylation sites or proteolytic cleavage. In this review, we present an overview of the regulatory mechanisms governing host cell FAs, and provide examples of how pathogenic microbes have evolved to co-opt them to their own advantage. Recent technological advances pose exciting opportunities for delving deeper into the mechanistic details by which pathogenic microbes modify FAs. |
| Databáze: | OpenAIRE |
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