Relation of alcohol/tobacco use with metastasis, hormonal (estrogen and progesterone) receptor status and c-erbB2 protein in mammary ductal carcinoma
Autor: | Esaú Floriano Sánchez, Cesar Miguel Mejia Barradas, Eleazar Lara Padilla, Noemi Cardenas Rodriguez, Saul Renan Leon-Hernandez, Alfredo Cortes Algara, Jaime Lopez Cruz, Cindy Bandala |
---|---|
Rok vydání: | 2014 |
Předmět: |
Adult
Cancer Research medicine.medical_specialty Alcohol Drinking Epidemiology medicine.drug_class Receptor ErbB-2 Estrogen receptor Breast Neoplasms Metastasis Tobacco Use Breast cancer Internal medicine Progesterone receptor Medicine Humans Neoplasm Metastasis Receptor Mexico Aged Aged 80 and over business.industry Carcinoma Ductal Breast Public Health Environmental and Occupational Health Progesterone Receptor Status Ductal carcinoma Middle Aged medicine.disease Endocrinology Oncology Receptors Estrogen Estrogen Female business Receptors Progesterone |
Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 15(14) |
ISSN: | 2476-762X |
Popis: | Background: An association between alcohol/tobacco use and risk of metastasis in breast cancer has been clearly shown. Materials and Methods: The present study explored, in 48 samples of tissue from mammary ductal carcinoma (taken from Mexican women with an average age of 58.2±10.9 years), the association of risk of metastasis with the status of hormonal receptors and the c-erbB2 protein (by immunohistochemistry) as well as clinical, histopathological and sociodemographic factors. Results: Of 48 patients, 41.6% (20/48) presented with metastasis, 43.8% were positive for the estrogen receptor (RE+), 31.3% for the progesterone receptor (RP+) and 47.7% for c-erbB2 (c-erbB2+). The following combinations were found: RE+/RP+/c-erbB2+ 8.3%, RE+/RP+ 22.9%, RE+/RP- 20.8%, RE-/RP+ 8.3%, RE-/RP-/c-erbB2- 22.9% and RE-/RP- 47.8%. There were 12 patients who used alcohol/tobacco, of which 91.6% did not present metastasis and 81.9% were RE-/RP-. Compared to the RE-/RP-/c-erbB2+, the RE+/RP+/c-erbB2+ group had a 15-fold greater risk for metastasis (95%CI, 0.9-228.8, p=0.05). The carriers of the double negative hormonal receptors had a 4.7 fold greater probability of being (or having been) smokers or drinkers (95%CI, 1.0-20.4, p = 0.03). Conclusions: There was a clear protective effect of using alcohol and/or tobacco, in the cases included in the present study of mammary ductal carcinoma, associated with double negative hormonal receptors. However, this association could be due to a protective factor not measured (Neyman bias) or to a bias inherent in the rate of hospitalization (Berkson fallacy). This question should be explored in a broad prospective longitudinal study. |
Databáze: | OpenAIRE |
Externí odkaz: |