Induction of apoptosis by immature fruits ofPrunus salicinaLindl. cv. Soldam in MDA-MB-231 human breast cancer cells
| Autor: | Mi Hee Yu, Hyo Gwon Im, Syng-Ook Lee, In-Seon Lee, Chang Sung, Dong-Cheol Park |
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| Rok vydání: | 2007 |
| Předmět: |
Prunus salicina
Blotting Western Apoptosis Breast Neoplasms Caspase 3 DNA Fragmentation Biology Caspase 7 Andrology Prunus Bcl-2-associated X protein Phenols Tumor Cells Cultured Humans bcl-2-Associated X Protein Flavonoids Traditional medicine Plant Extracts Polyphenols food and beverages Flow Cytometry biology.organism_classification Caspase 9 Proto-Oncogene Proteins c-bcl-2 Proanthocyanidin Polyphenol Fruit biology.protein Female Poly(ADP-ribose) Polymerases Tannins Biomarkers Phytotherapy Food Science |
| Zdroj: | International Journal of Food Sciences and Nutrition. 58:42-53 |
| ISSN: | 1465-3478 0963-7486 |
| DOI: | 10.1080/09637480601121938 |
| Popis: | The goal of this study was to evaluate the anticancer effect of Prunus salicina Lindl. cv. Soldam at three maturity stages (immature, midmature and mature stages). Previous studies have shown that this fruit (plums) possesses hematopoiesis effects, prevents osteoporosis and has anti-mutagenic effects. An acetone extract of immature P. salicina Lindl. cv. Soldam fruit contained higher levels of total phenolics and condensed tannins than midmature and mature plums. The results showed that an acetone extract of immature plums possesses cytotoxic effects, which are related to the activity of the total polyphenols in the fruits. Apoptosis in MDA-MB-231 cells mediated by the immature plums was associated with an increase in Bax levels and a reduction in Bcl-2 levels and the cleavage of caspase 3, caspase 7, caspase 9 and poly-(ADP-ribose) polymerase. These results indicate that immature fruit of P . salicina Lindl. cv. Soldam can be regarded as a safe and promising new dietary source for decreasing the risk of developing breast cancer. |
| Databáze: | OpenAIRE |
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