Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance
| Autor: | Qiong Wan, Xiang Ma, Li Wei Li, Zhi Gang Cheng, Xu Yong Dai, Guang Ya Xiang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
barnidipine hydrochloride
impurities antihypertensive agent Barnidipine Nifedipine medicine.drug_class Hydrochloride Pharmaceutical Science High-performance liquid chromatography Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Impurity Drug Discovery medicine Physical and Theoretical Chemistry Antihypertensive drug Spectral data Nuclear Magnetic Resonance Biomolecular Antihypertensive Agents Chromatography Molecular Structure Chemistry Organic Chemistry Calcium Channel Blockers Chemistry (miscellaneous) Molecular Medicine Drug Contamination Dihydropyridine Calcium Channel Blocker medicine.drug |
| Zdroj: | Molecules; Volume 19; Issue 1; Pages: 1344-1352 Molecules Molecules, Vol 19, Iss 1, Pp 1344-1352 (2014) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules19011344 |
| Popis: | Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm × 4.6 mm, 5 µm). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). The identification of these impurities should be useful for quality control in the manufacture of barnidipine. |
| Databáze: | OpenAIRE |
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