Impaired mastication reduced newly generated neurons at the accessory olfactory bulb and pheromonal responses in mice
| Autor: | Sadaharu Miyazono, Kazumi Osada, Makoto Kashiwayanagi, Chizuru Utsugi, Mitsuyoshi Matsuda |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Olfactory system Time Factors Vomeronasal organ Soft diet Neurogenesis Pheromone Subventricular zone Sensory system Biology Pheromones Mice medicine Animals General Dentistry Mastication Hard diet Cell Biology General Medicine Anatomy Immunohistochemistry Olfactory Bulb Diet Cell biology Olfactory bulb Mice Inbred C57BL Smell medicine.anatomical_structure Bromodeoxyuridine nervous system Otorhinolaryngology Olfactory function Female Proto-Oncogene Proteins c-fos |
| Zdroj: | Archives of Oral Biology. 59:1272-1278 |
| ISSN: | 0003-9969 |
| Popis: | Objectives A large number of neurons are generated at the subventricular zone (SVZ) even during adulthood. In a previous study, we have shown that a reduced mastication impairs both neurogenesis in the SVZ and olfactory functions. Pheromonal signals, which are received by the vomeronasal organ, provide information about reproductive and social states. Vomeronasal sensory neurons project to the accessory olfactory bulb (AOB) located on the dorso-caudal surface of the main olfactory bulb. Newly generated neurons at the SVZ migrate to the AOB and differentiate into granule cells and periglomerular cells. This study aimed to explore the effects of changes in mastication on newly generated neurons and pheromonal responses. Design Bromodeoxyuridine-immunoreactive (BrdU-ir; a marker of DNA synthesis) and Fos-ir (a marker of neurons excited) structures in sagittal sections of the AOB after exposure to urinary odours were compared between the mice fed soft and hard diets. Results The density of BrdU-ir cells in the AOB in the soft-diet-fed mice after 1 month was essentially similar to that of the hard-diet-fed mice, while that was lower in the soft-diet-fed mice for 3 or 6 months than in the hard-diet-fed mice. The density of Fos-ir cells in the soft-diet-fed mice after 2 months was essentially similar to that in the hard-diet-fed mice, while that was lower in the soft-diet-fed mice for 4 months than in the hard-diet-fed mice. Conclusions The present results suggest that impaired mastication reduces newly generated neurons at the AOB, which in turn impairs olfactory function at the AOB. |
| Databáze: | OpenAIRE |
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