Deletion of Nrf2 reduces skeletal mechanical properties and decreases load-driven bone formation

Autor:	Yong-Xin Sun, Guoli Dai, Lei Li, Pei Zhang, Kylie A. Corry, Evan R. Himes, Yang Yang, Jiliang Li, Cristina Layla Mihuti, Cecilia Nelson
Rok vydání:	2014
Předmět:	Male medicine.medical_specialty Cell type Histology Physiology NF-E2-Related Factor 2 Endocrinology Diabetes and Metabolism Acid Phosphatase Oxidative phosphorylation medicine.disease_cause digestive system environment and public health Antioxidants Bone and Bones Wnt-5a Protein Bone remodeling Weight-Bearing Osteogenesis Internal medicine Gene expression medicine Animals Femur RNA Messenger Bone Resorption Transcription factor Fluorescent Dyes Mice Knockout Mutation Lumbar Vertebrae Chemistry Tartrate-Resistant Acid Phosphatase Osteoblast respiratory system Biomechanical Phenomena WNT5A Isoenzymes Mice Inbred C57BL Wnt Proteins Endocrinology medicine.anatomical_structure Gene Expression Regulation Gene Deletion
Zdroj:	Bone. 74
ISSN:	1873-2763
Popis:	Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor expressed in many cell types, including osteoblasts, osteocytes, and osteoclasts. Nrf2 has been considered a master regulator of cytoprotective genes against oxidative and chemical insults. The lack of Nrf2 can induce pathologies in multiple organs. The aim of this study was to investigate the role of Nrf2 in load-driven bone metabolism using Nrf2 knockout (KO) mice. Compared to age-matched littermate wild-type controls, Nrf2 KO mice have significantly lowered femoral bone mineral density (-7%, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd7a1baaaa41e14f21f21e5455209e9 https://pubmed.ncbi.nlm.nih.gov/25576674 Zobrazit plný text záznamu Full Text from ScienceDirect