Datasets on the genomic positions of the MLL1 morphemes, the ZFP57 binding site, and ZFBS-Morph overlaps in the build mm9 of the mouse genome
| Autor: | Xiaohui C. Song, Minou Bina, Phillip J. Wyss |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
mouse genome Biology lcsh:Computer applications to medicine. Medical informatics Genome DNA sequencing 03 medical and health sciences chemistry.chemical_compound Transcription (biology) lcsh:Science (General) Data Article Regulation of gene expression Genetics Multidisciplinary 030102 biochemistry & molecular biology KMT2AMLL1 morphemes KMT2A genomic imprinting Chemistry genomic DNA 030104 developmental biology Differentially methylated regions chemistry CpG-rich motifs MLL1 morphemes ZFP57 binding site lcsh:R858-859.7 gene regulation Genomic imprinting DNA lcsh:Q1-390 |
| Zdroj: | Data in Brief, Vol 13, Iss, Pp 202-207 (2017) Department of Chemistry Faculty Publications Data in Brief |
| ISSN: | 2352-3409 |
| DOI: | 10.1016/j.dib.2017.05.050 |
| Popis: | While MLL1 activates gene expression in most tissues, ZFP57 represses transcription. MLL1 selectively interacts with a group of nonmethylated DNA sequences known as the MLL1 morphemes. ZFP57 associates with a methylated hexamer (ZFBS), dispersed in the genomic DNA segments known as Imprinted Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs), to maintain allele-specific gene repression. We have identified a set of composite DNA elements (ZFBS-Morph overlaps) that provides the sequence context of ZFBS in the canonical ICRs/gDMRs. This report provides tables listing the nucleotide sequences of the MLL1 morphemes and ZFBS-Morph overlaps. The report also offers links to the data repository at Purdue University, for downloading the positions of the MLL1 morphemes, the ZFP57 binding site, and the ZFBS-Morph overlaps in the mouse genome. Keywords: CpG-rich motifs, Gene regulation, Genomic imprinting, KMT2A, MLL1 morphemes, Mouse genome, ZFP57 binding site |
| Databáze: | OpenAIRE |
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