Data on the endogenous conversion of tyrosolinto hydroxytyrosol in humans
| Autor: | Boronat Rigol, Anna, Mateus Rodríguez, Julián Andrés, Soldevila Domènech, Natàlia, Guerra, Mercé, Rodriguez Morato, Jose, Varon, Carlota, Muñoz, Daniel, Barbosa, Francina, Morales, Juan Carlos, Gaedigk, Andreas, Langohr, Klaus, Covas, Maria Isabel, Pérez Mañá, Clara, Fitó Colomer, Montserrat, Tyndale, Rachel F., De la Torre Fornell, Rafael |
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| Přispěvatelé: | Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
CYP2D6 CYP2A6 Biomatemàtica Endogenous conversion Matemàtiques i estadística::Matemàtica aplicada a les ciències [Àrees temàtiques de la UPC] Endogeny 030204 cardiovascular system & hematology lcsh:Computer applications to medicine. Medical informatics Cardiovascular risks law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Tyrosol Anàlisi multivariable Hydroxytyrosol lcsh:Science (General) 030304 developmental biology Biomathematics 0303 health sciences Multidisciplinary Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària [Àrees temàtiques de la UPC] business.industry 92 Biology and other natural sciences::92B Mathematical biology in general [Classificació AMS] 62 Statistics::62H Multivariate analysis [Classificació AMS] Cardiovascular risk Nursing and Health Profession 3. Good health Original data Endocrinology chemistry Multivariate analysis White Wine lcsh:R858-859.7 business lcsh:Q1-390 |
| Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Data in Brief, Vol 27, Iss, Pp-(2019) UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Data in Brief Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ Here we present new and original data on the endogenous con-version of tyrosol (Tyr) into hydroxytyrosol (OHTyr) in humans and its effects on the cardiovascular system. A randomized,crossover, controlled clinical trial was performed with individuals at cardiovascular risk (n¼33). They received white wine (WW)(females 1, males 2 standard drinks/day), WW plus Tyr capsules(WWþTyr) (25mg Tyr capsule, one per WW drink), and water(control)ad libitum. Intervention periods were of 4 weeks pre-ceded by three-week wash-out periods. We assessed the conversion of Tyr to OHTyr, its interaction with a polygenic activity score(PAS) fromCYP2A6andCYP2D6genotypes, and the effects on cardiovascular risk markers. For further details and experimental findings please refer to the article“Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol Inhumans. A randomized, controlled trial” |
| Databáze: | OpenAIRE |
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