Comparative Study of Postmortem Concentrations of Antidepressants in Several Different Matrices
| Autor: | Kari Beate Boye Eldor, Marianne Arnestad, Mariana Dadalto Peres, Sidsel Rogde, Stian Nilsen, Gerd-Wenche Brochmann, Lena Kristoffersen, Åse Marit Leere Øiestad, Elisabeth Leere Øiestad, Ritva Karinen, Vigdis Vindenes |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Health
Toxicology and Mutagenesis Mirtazapine Venlafaxine Pharmacology Citalopram Toxicology 01 natural sciences Analytical Chemistry 03 medical and health sciences Forensic Toxicology 0302 clinical medicine medicine Environmental Chemistry Humans 030216 legal & forensic medicine Muscle Skeletal Chemical Health and Safety Vitreous humour Chemistry 010401 analytical chemistry Forensic toxicology Trimipramine Mianserin Antidepressive Agents 0104 chemical sciences Substance Abuse Detection Vitreous Body Postmortem Changes Pericardial Fluid Nortriptyline Autopsy medicine.drug |
| Zdroj: | Journal of analytical toxicology. 42(7) |
| ISSN: | 1945-2403 0146-4760 |
| Popis: | Peripheral blood (PB) is considered to be the golden standard for measuring postmortem drug concentrations. In several cases, PB is however not available, but information regarding drug findings might still be crucial in order to determine the cause of death. Antidepressants are frequently detected in postmortem samples from forensic toxicology cases, but the literature investigating concentrations in other matrices than peripheral and heart blood is limited. We here describe a study for comparison of concentrations for a large number of different drugs in six different matrices. A total of 173 postmortem cases were included in the study material. The results from 44 cases with findings of antidepressants (amitriptyline/nortriptyline, citalopram, mianserin, mirtazapine, paroxetine, sertraline, trimipramine and venlafaxine) are presented in this article. Concentrations in peripheral and cardiac blood (CB), pericardial fluid (PF), two muscle samples and vitreous humour (VH) are compared. Ratios between concentrations in different matrices have also been compiled from available literature. All the investigated antidepressants were detected in all different matrices, and comparable concentration levels were found in the different matrices with a few exceptions. Concentrations in VH were generally lower than in the other matrices, and in a few cases with low concentrations in blood the antidepressants were not detected in VH. For most of the cases, ratios of 0.5–2 were found between concentration in PB and that in the other matrices. Some deviant concentrations where however found. This study shows that CB, PF, muscle and VH can provide important indications of the corresponding concentrations in PB when PB is not available. |
| Databáze: | OpenAIRE |
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