Olfactory and gustatory dysfunctions in COVID-19 outpatients: A prospective cohort study
| Autor: | D Bendetowicz, Christine Katlama, C Delorme, A. L. Ndoadoumgue, B. Abdi, B. Sellem, Marc-Antoine Valantin, Romain Palich, Sophie Seang, Lambert Assoumou, Luminita Schneider, Roland Tubiana, L Cousyn, Yasmine Dudoit, R Agher, A. Faycal |
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| Přispěvatelé: | Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de Virologie [CHU Pitié-Salpêtrière], Gestionnaire, Hal Sorbonne Université, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de virologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Taste Coronavirus disease 2019 (COVID-19) [SDV]Life Sciences [q-bio] medicine.medical_treatment Anosmia Late recovery Article Cohort Studies 03 medical and health sciences Olfaction Disorders Taste Disorders 0302 clinical medicine Recovery rate Risk Factors Internal medicine medicine Ambulatory Care Humans Prospective Studies ageusia 030223 otorhinolaryngology Prospective cohort study Rehabilitation General symptoms business.industry Proportional hazards model SARS-CoV-2 COVID-19 Middle Aged 3. Good health [SDV] Life Sciences [q-bio] carbohydrates (lipids) Smell Infectious Diseases nervous system Female business 030217 neurology & neurosurgery |
| Zdroj: | Infectious Diseases Now Infectious Diseases Now, 2021, 128 (2), pp.376-383. ⟨10.1016/j.idnow.2021.03.004⟩ Infectious Diseases Now, Elsevier, 2021, 128 (2), pp.376-383. ⟨10.1016/j.idnow.2021.03.004⟩ |
| ISSN: | 2666-9919 |
| DOI: | 10.1016/j.idnow.2021.03.004⟩ |
| Popis: | International audience; Objectives: To describe the characteristics, evolution and risk factors for long-term persistence of olfactory and gustatory dysfunctions (OGD) in COVID-19 outpatients.Patients and methods: We conducted a prospective study in SARS-CoV-2 infected outpatients with OGD. Weekly phone interviews were set up starting from COVID-19 onset symptoms and over the course of 60 days, using standardized questionnaires that included a detailed description of general symptoms and OGD. The primary outcome was the proportion of patients with complete recovery of OGD at D30. Rate and time to recovery of OGD, as well as risk factors for late recovery (>30 days), were evaluated using Cox regression models.Results: Ninety-eight outpatients were included. The median time to onset of OGD after first COVID-19 symptoms was 2 days (IQR 0-4). The 30-day recovery rate from OGD was 67.5% (95% CI 57.1-75.4) and the estimated median time of OGD recovery was 20 days (95% CI 13-26). Risk factors for late recovery of OGD were a complete loss of smell or taste at diagnosis (HR=0.26, 95% CI 0.12-0.56, P=0.0005) and age over 40 years (HR=0.56, 95% CI 0.36-0.89, P=0.01).Conclusions: COVID-19 patients with complete loss of smell or taste and over age 40 are more likely to develop persistent OGD and should rapidly receive sensorial rehabilitation. |
| Databáze: | OpenAIRE |
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