Validation of a novel method for continuous saline tonometry in a porcine model
| Autor: | Tomas Bäcklund, Karl-Axel Ängquist, Mats Häggström, Conny Arnerlöv, Bengt Hedberg, Rolf Fröjse, Olof Lindahl |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Manometry Swine Physiology medicine.medical_treatment Biomedical Engineering Biophysics In Vitro Techniques Sodium Chloride Gastric Acid Physiology (medical) Animals Medicine Physiological saline Saline Monitoring Physiologic business.industry Stomach Hemodynamics Hydrogen-Ion Concentration Surgery Haemodynamically stable Models Animal Continuous perfusion business Biomedical engineering |
| Zdroj: | Physiological Measurement. 22:453-460 |
| ISSN: | 1361-6579 0967-3334 |
| DOI: | 10.1088/0967-3334/22/3/304 |
| Popis: | Only intermittent and semi-continuous tonometric measurement of gastric and intestinal pHi is possible with the equipment available today. Earlier we developed a system for continuous saline tonometry and tested it in vitro. To assess the in vivo reliability of this method for continuous gastrointestinal saline tonometry, a standard tonometer for measurement of intestinal pCO2 and corresponding pHi was modified to allow continuous perfusion of physiological saline in a closed system and tested in a porcine model. In 11 anaesthetized and haemodynamically stable pigs, two continuous tonometry balloons were inserted into the distal small bowel, and a standard tonometry balloon was used as reference. To test long-term function of the continuous tonometers the research protocol lasted for eight hours. The two continuous saline tonometers performed well, and after an equilibration time of three hours the mean pHi values were stable between 7.35 and 7.43 and between 7.32 and 7.39 respectively. The standard tonometer measured stable pHi values. These preliminary studies indicate that continuous saline tonometry performs well over eight hours with a small bias and a good precision. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|