Hemorheology and oxidative stress in patients with differentiated thyroid cancer following I-131 ablation/metastasis treatment
| Autor: | Tarık Şengöz, Emine Kilic-Toprak, Yasin Ozdemir, Melek Bor-Kucukatay, Burak Oymak, Olga Yaylali, Ozgen Kilic-Erkek, Vural Kucukatay, Hande Senol, Doğangün Yüksel |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
erythrocyte deformability
Male leukocyte count thyroid tumor radioactive iodine 030204 cardiovascular system & hematology medicine.disease_cause Gastroenterology Erythrocyte aggregation 030218 nuclear medicine & medical imaging Iodine Radioisotopes thyrotropin mean corpuscular hemoglobin 0302 clinical medicine middle aged Erythrocyte deformability oxidative stress oxidizing agent Iodine-131 Neoplasm Metastasis Thyroid cancer blood rheology clinical article mean corpuscular volume adult Thyroid Pascal (unit) Hematology Venous blood Differentiated thyroid cancer total oxidant level medicine.anatomical_structure female erythrocyte count thyroidectomy histopathology total antioxidant level levothyroxine sodium triacylglycerol Cardiology and Cardiovascular Medicine ferrous sulfate medicine.medical_specialty hematocrit microcirculation hydrogen peroxide Article shear stress 03 medical and health sciences blood Physiology (medical) Internal medicine medicine thyroid metastasis metastasis Humans controlled study human Thyroid Neoplasms dianisidine hydroxyl radical business.industry iodine 131 hormone substitution I-131 hemoglobin antioxidant assay case control study medicine.disease ablation therapy human tissue ferric ion Case-Control Studies oxidative stress index physiology Hemorheology colorimetry fibrinogen erythrocyte aggregation red blood cell distribution width business Oxidative stress |
| Popis: | BACKGROUND: Although radioiodine theraphy (RAIT) is thought to affect blood cells and oxidative stress, hemorheological alterations following dose-dependent RAIT remains unknown. OBJECTIVE: The aim of this study was to determine the effects of RAIT on hemorheological and oxidative stress parameters in patients with differentiated thyroid cancers (DTC). METHODS: Totally 31 DTC patients (mean age 46.32±11.15 years) and 26 healthy controls (mean age 50.50±6.22 years) were included. Venous blood samples were collected from each patient before and after treatment (7th day, 1th month and 6th month). Erythrocyte aggregation-deformability and oxidative stress parameters were determined. p < 0.05 was considered as statistically significant. RESULTS: Erythrocyte deformability of the patients determined at 16.87 and 30 Pascal were significantly lower than healthy individuals. Erythrocyte aggregation index (AI) of the patients was higher, whereas erythrocyte aggregation half-time (t½) was lower compared to control. Erythrocyte deformability values and AI were not significantly different from the pre-and post-radioiodine treatment groups. There was no statistically significant difference between the oxidative stress parameters before and after the treatment. CONCLUSIONS: Patients were in a worse hemorheological condition compared to healthy individuals. After RAIT, RBC deformability and aggregation were not affected and no significant change in oxidative stress parameters was detected. © 2020-IOS Press and the authors. All rights reserved. |
| Databáze: | OpenAIRE |
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