Canonical transient receptor potential channels and their modulators: biology, pharmacology and therapeutic potentials
| Autor: | Wen Tian, Yang Sun, Hui-Nan Zhang, Xiao-Qiang Li, Wei Cao, Yuan-Yuan Gao, Jing-Ru Meng |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Anti-Inflammatory Agents Review Biology TRPC5 TRPC4 TRPC1 03 medical and health sciences Transient receptor potential channel 0302 clinical medicine TRPC3 Canonical transient receptor potential channels modulators Calcium ion Humans Disease TRPC Cation Channels Drug discovery Organic Chemistry High-resolution structures Therapeutic potentials Additional research 030104 developmental biology 030220 oncology & carcinogenesis Molecular Medicine High calcium Neuroscience |
| Zdroj: | Archives of Pharmacal Research |
| ISSN: | 1976-3786 |
| Popis: | Canonical transient receptor potential channels (TRPCs) are nonselective, high calcium permeability cationic channels. The TRPCs family includes TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7. These channels are widely expressed in the cardiovascular and nervous systems and exist in many other human tissues and cell types, playing several crucial roles in the human physiological and pathological processes. Hence, the emergence of TRPCs modulators can help investigate these channels' applications in health and disease. It is worth noting that the TRPCs subfamilies have structural and functional similarities, which presents a significant difficulty in screening and discovering of TRPCs modulators. In the past few years, only a limited number of selective modulators of TRPCs were detected; thus, additional research on more potent and more selective TRPCs modulators is needed. The present review focuses on the striking desired therapeutic effects of TRPCs modulators, which provides intel on the structural modification of TRPCs modulators and further pharmacological research. Importantly, TRPCs modulators can significantly facilitate future studies of TRPCs and TRPCs related diseases. |
| Databáze: | OpenAIRE |
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